UNC-2170

Active Motif | Article no.: 14120
PDF Type Clone Specific against Application Host Quantity Price
Small Molecules & Inhibitors 25 mg 275,– €
Description The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-stranded DNA breaks. UNC-2170, identified by screening, was found to be a uM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.
Alternative Names methylation, methyl-binding protein, 53BP1, H4K20me2, histone, inhibitor, DNA damage
Weblink https://www.activemotif.com/catalog/details/14120
Datasheet https://www.activemotif.com/documents/tds/14120.pdf
Transportation RT
Storage -20°C


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