Human CD4 / LEU3 Protein, His Tag (MALS verified)

Description	Human CD4, His Tag (LE3-H5228) is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Trp 390 (Accession # AAH25782). T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients. This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 41.5 kDa. The protein migrates as 47-54 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Conjugate	Unconjugated
Weblink	https://www.acrobiosystems.com/P1387-Human-CD4--LEU3-Protein-His-Tag-%28MALS-verified%29.html
Datasheet	https://www.acrobiosystems.com/static/main/products/pdf/ds/LE3-H5228.pdf
Transportation	RT
Storage	-20°C