SARS-CoV-2 Spike S1 Protein (T95I, G142D, E154K, L452R, E484Q, D614G, P681R), His Tag

ACROBiosystems | Article no.: S1N-C52Ht-1mg
PDF Type Clone Specific against Application Host Quantity Price
Proteins & Peptides HEK 293 1mg 2.905,– €
Description SARS-CoV-2 Spike S1, His Tag (S1N-C52Ht) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685 (Accession # QHD43416.1). The mutations (T95I, G142D, E154K, L452R, E484Q, D614G, P681R) were identified in the SARS-CoV-2 Kappa variant (Pango lineage: B.1.617.1; other names: 21A/S:154K).

It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 77.0 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Conjugate Unconjugated
Weblink https://www.acrobiosystems.com/products/protein/spike-s1-sars-cov-2-s1n-c52ht
Datasheet https://console.acrobiosystems.com/public/product/pdf/ds/S1N-C52Ht.pdf
Transportation RT
Storage -20°C


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