Ep300 Polyclonal Antibody

Bioss | Article no.: bs-6954R
PDF Type Clone Specific against Application Host Quantity Price
Primary Antibodies, PUB25 Human, Murine / Mouse Western blot, ELISA, IHC-P, IHC-Fr, IF Rabbit 100µL 435,– €
326,25 €
Description Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB which is activated as a result of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.
Alternative Names CREBBP/EP300 inhibitory protein 1, Cyclic AMP responsive enhancer binding protein, E1A associated protein p300, E1A binding protein p300, E1A-associated protein p300, EC 2.3.1.48, EP300, EP300: E1A binding protein p300, EP300_HUMAN, istone acetyltransferase p300, 300 HAT, RB and P300 binding protein EID 1, Retinoblastoma protein associated protein, RSTS2.
Conjugate Unconjugated
Isotype Antibody IgG
Type Antibody Polyclonal
Weblink https://www.biossusa.com/products/bs-6954r
Datasheet https://www.biossantibodies.com/datasheets/bs-6954R
Storage -20°C


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