Anti-Hu CD264 Purified Azide Free
Exbio
| Article no.: 10-519-C100
| Type | Clone | Specific against | Application | Host | Quantity | Price | |
|---|---|---|---|---|---|---|---|
| Primary Antibodies | TRAIL-R4-01 | Human | Flow cytometry | Murine / Mouse | 0.1 mg | 278,– € |
| Description | TRAIL-R4 (CD264, TR4, DcR2, TRUNDD), expressed mainly on CD8+ and NK cells, belongs to receptors of TRAIL, a TNF-like membrane toxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4, however, contains partially truncated death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing. TRAIL-R4 interacts with death receptor 5 (DR5) in the native DISC in a TRAIL-dependent manner and prevents its corecruitment with death receptor 4 (DR4). |
|---|---|
| Clonality | TRAIL-R4-01 |
| Conjugate | Unconjugated |
| Isotype Antibody | IgG1 |
| Storage | +4°C |
Contact Veronika Hackl & Andrea Grössmann for orders:
orders.lsr@thp.at
+43 664 968 29 68
+43 1 292 820 80 - 225