Anti-Ms CD18 FITC
Exbio
| Article no.: 1F-623-C100
| Type | Clone | Specific against | Application | Host | Quantity | Price | |
|---|---|---|---|---|---|---|---|
| Primary Antibodies | M18/2 | Murine / Mouse | Flow cytometry | Rat | 0.1 mg | 231,– € |
| Description | CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis. |
|---|---|
| Clonality | M18/2 |
| Conjugate | FITC |
| Isotype Antibody | IgG2a |
| Storage | +4°C |
Contact Veronika Hackl & Andrea Grössmann for orders:
orders.lsr@thp.at
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+43 1 292 820 80 - 225