5-Octyl-α-ketoglutarate
MedChem Express (MCE)
| Article no.: HY-145452-1mg
| Type | Clone | Specific against | Application | Host | Quantity | Price | |
|---|---|---|---|---|---|---|---|
| Chemicals & Compounds | 1mg | 264,– € |
| Description | 5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1]. |
|---|---|
| Alternative Names | 5-Octyl 2-oxopentanedioate |
| Weblink | https://www.medchemexpress.com/5-octyl-α-ketoglutarate.html |
| Datasheet | http://file.medchemexpress.com/batch_PDF/HY-145452/5-Octyl-α-ketoglutarate-DataSheet-MedChemExpress.pdf |
| Transportation | RT |
| CAS | 1616344-00-3 |
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